Here we sequenced and assembled the genome of a captive sooty mangabey. We conducted genome-wide comparative analyses of …
The proposed studies are aimed at understanding why the sooty mangabeys are able to remain healthy when infected with SIV.
Sooty mangabeys are an important animal model for research related to human immunodeficiency virus (HIV) and AIDS. Rhesus macaques are used to model human immunodeficiency virus type 1 (HIV-1) infections, but they are not natural hosts of HIV-1 or any simian immunodeficiency virus (SIV). Sooty mangabeys are the natural hosts for a simian immunodeficiency virus (SIV), and HIV-2 is derived from that SIV, likely as a result of cross-species transfer of the SIV. Chen Z, Telfier P, Gettie A, et al. In contrast, SIV infection of nonnatural hosts such as rhesus macaques (RMs) induces an AIDS-like disease. Sooty mangabeys are naturally infected with a strain of Simian Immunodeficiency Virus (SIV), known as SIVsmm. Sooty mangabeys, a type of African monkey, have intrigued scientists for years because they can survive infection by SIV, a relative of HIV, and not succumb to AIDS. The less common HIV-2 came from sooty mangabey monkeys. In sooty mangabeys, a less active form of TLR4 may reduce immune activation in response to SIV infection. SIV infection of sooty mangabeys (SMs), a natural host species, does not cause AIDS despite high-level virus replication.
-HIV-2 groups A and B must have originated from two separate sooty mangabey-to-human transmissions for similar reasons.
Both of these events likely happened when the animals were killed and processed as food. Due to extensive human-mangabey contact in sub-Saharan Africa, SIVsmm has jumped from this species into humans on many occasions, resulting in HIV-2 virus. Researchers have identified a way some of sooty mangabeys’ immune cells resist infection: they close the gates that SIV and HIV use to get into the cell.
Sooty mangabeys do not progress to AIDS despite being naturally infected with SIV, a virus closely related to HIV. Genetic characterization of new West African simian immunodeficiency virus SIVsm: geographic clustering of household-derived SIV strains with human immunodeficiency virus type 2 subtypes and genetically diverse viruses from a single feral sooty mangabey troop. In contrast to infections with human immunodeficiency virus (HIV) in humans and simian immunodeficiency virus (SIV) in macaques, SIV infection of a natural host, sooty mangabeys (Cercocebus atys), is non-pathogenic despite high viraemia.
Rather, they became infected with SIV through cross-species transfer from sooty mangabeys in … A key feature differentiating nonpathogenic SIV infection of sooty mangabeys (SMs) from pathogenic HIV/SIV infections is the rapid resolution of type I IFN (IFN-I) responses and IFN-stimulated gene expression during the acute-to-chronic phase transition and the establishment of an immune quiescent state that persists throughout the chronic infection.
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