Liu, P., Chen, W. & Chen, J. P. Viral metagenomics revealed Sendai virus and coronavirus infection of Malayan pangolins (Manis javanica). More than five substitutions were observed in turtle (Chrysemys picta bellii, Chelonia mydas, and Pelodiscus sinensis), pangolin (Manis javanica), and bat (both Rhinolophus sinicus and R. pearsonii) receptors in contrast to the theoretical infection‐permissive species, such as human, gorilla, and macaca (Table 1). US President Donald Trump has fuelled suggestions that the virus might have leaked from a laboratory in Wuhan, where the outbreak started. The pandemic of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has posed a severe threat to global public health. identified SARS-CoV-2-related viruses in pangolins, providing novel insights into the evolution and diversity of SARS-CoV-2-related viruses. [11] The emerging SARS-coronavirus 2 (SARS-CoV-2) poses tremendous threat to human health. Yet, the origin of SARS-CoV-2 remains mysterious. Severe respiratory syndrome coronavirus‐2 (SARS‐CoV‐2), a novel coronavirus, caused Coronavirus Disease 2019 ... Chelonia mydas, and Pelodiscus sinensis), pangolin (Manis javanica), and bat (both Rhinolophus sinicus and R. pearsonii) receptors in contrast to the theoretical infection‐permissive species, such as human, gorilla, and macaca (Table 1). Viruses 11 , 979 (2019). Coronavirus and COVID-19: Keep up to date. New coronavirus strains have been identified in pangolins smuggled into China, researchers report in Nature. Author information: (1)Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, … Researchers isolated coronaviruses from Malayan pangolins (Manis javanica) confiscated during anti-smuggling operations in southern China 11, 12. The current outbreak of a novel coronavirus 2019_nCoV (now named SARS‐CoV‐2) that started in December 2019 in the city of Wuhan, Hubei, China, once again demonstrates the risk of emerging zoonotic viral infections in general, and that of coronavirus species in particular. According to previous studies by metagenomic sequencing for the samples from Malayan pangolins (Manis javanica) in Guangxi and Guangdong, China, it has been suggested that pangolins might be the intermediate hosts between bats and humans because of the similarity of the pangolin coronavirus to SARS-CoV-2 [32,33]. CAS Article Google Scholar Several recent studies (e.g., Lam et al., Xiao et al.) Alignment between 2019-nCoV and the coronavirus infecting Manis javanica lung (Manis-CoV). Protein coding genes are indicated by thick arrows. Viral Metagenomics Revealed Sendai Virus and Coronavirus Infection of Malayan Pangolins (Manis javanica). In particular, the alignments of the spike surface glycoprotein receptor binding domain revealed four times more variations in the bat coronavirus RaTG13 than in the Manis coronavirus compared … Genome … Zhang, Wu et al. Liu, P., Chen, W. & Chen, J. P. Viral metagenomics revealed sendai virus and coronavirus infection of Malayan pangolins (Manis javanica). Viruses 12 , 11 (2019). show that like bats, pangolin species are a natural reservoir of SARS-CoV-2-like CoVs. identified SARS-CoV-2-related viruses in pangolins, providing novel insights into the evolution and diversity of SARS-CoV-2-related viruses. (A) Schematic of the alignment between the 2019-nCoV full genome (thin black line) and the draft genome of Manis-CoV, where thick black lines are aligned regions. Only unmapped reads were mapped to the SARS-CoV-2 reference genome (GenBank: MN908947) for identifying virus reads. Liu P(1), Chen W(2), Chen JP(3). Considering that the earliest coronavirus disease 2019 (COVID-19) patient reported no exposure at the seafood ... remove host contamination, Bowtie2 (version 2.3.4.3) was used to map clean reads to the host reference genome of Manis javanica (SRA: PRJNA256023). The pandemic of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has posed a severe threat to global public health.
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